tirzepatide semaglutide head to head trial SURPASS-2 (NEJM 2021) was the definitive head-to-head: tirzepatide vs semaglutide 1.0 mg (the maximum approved T2DM dose) in 1,879 patients with type 2 diabetes. All three tirzepatide doses produced superior HbA1c reductions

Name: tirzepatide semaglutide head to head trial SURPASS-2 (NEJM 2021) was the definitive head-to-head: tirzepatide vs semaglutide 1.0 mg (the maximum approved T2DM dose) in 1,879 patients with type 2 diabetes. All three tirzepatide doses produced superior HbA1c reductions
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Risk of nonarteritic anterior ischemic optic neuropathy (NAION) in patients prescribed semaglutide - Novo Nordisk - Medical Update Online

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The FDA has proposed to bar 503B outsourcing facilities from bulk compounding semaglutide and tirzepatide. The shortage-list pathway already closed in 2024 and 2025; this proposal would remove the remaining bulks-list route.

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