tirzepatide surmount-1 nejm weight loss percent 72 weeks SURMOUNT-1 (NEJM 2022) tested tirzepatide — a dual GIP/GLP-1 receptor agonist — in 2,539 adults with obesity and achieved up to 20.9% mean weight loss at the highest dose. 57% of participants
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University of Pennsylvania researchers analyzed over 400,000 Reddit posts from nearly 70,000 users across five years and found that semaglutide and tirzepatide users are reporting menstrual irregularities and temperature complaints like chills
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